Exercise Strengthens Central Nervous System Modulation of Pain with Fibromyalgia

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    • #5252
      Michael McMurray
      Keymaster

      Exercise Strengthens Central Nervous System Modulation of Pain with Fibromyalgia

      In the last couple of months, while trying to improve how I treat patients with chronic pain, I have gone back to an article we discussed as a part of an in-service at my clinic in the first couple of weeks as a practicing clinician. I thought this would be something worthwhile to share as it has been a resource for me in treatment of this population. Also, I strongly believe in increasing physical activity in patients with chronic pain and thought this added to the evidence supporting it. And while a little over my head, I found the functional neuroimaging portion of this study to be very interesting.

      Objective
      To determine the effect of exercise on brain responses to pain in participants with fibromyalgia (FM).

      Methods
      Criteria for participation included physician diagnosed FM and between the ages of 18-60. Exclusionary criteria included the following: pregnancy, presence of ferrous metal in the body, left handedness, claustrophobia, medical conditions that would interfere with aerobic activity, major depressive disorder, and use of medications that would affect brain perception. 12 females were recruited for this study as well as 12 age and sex matched controls. 9 were used for final study analysis. Patients underwent functional neuroimaging (fMRI) scanning following exercise and quiet rest. The response to a series of painful stimuli was recorded. Outcome measures included the Fibromyalgia Impact Questionnaire and McGill Pain Questionnaire. Exercise conditions included performance of 25 minutes of moderate intensity cycling. Quiet rest included rested position on the same bike for 25 minutes. Following each condition, brain responses to noxious heat stimulate were measured using fMRI.

      Results
      Pain intensity and pain unpleasantness was moderately higher in participants with FM following quiet rest as compared to exercise. Post exercise and fMRI, the study participants reported decrease in pain symptoms on the McGill Pain Questionnaire as compared to an increase following quiet rest and fMRI. Following exercise, there was a significant within-group difference in participants with FM in terms of brain activity of the anterior insula and dorsolateral prefrontal cortex following exercises. Results showed 25 minutes of moderate intensity exercise resulted in short term influences on the descending pain modulating systems in FM.

      Conclusion
      Short duration, moderate intensity exercise resulted in improved pain modulation for participants with FM.

      Discussion points:

      1. What are your general thoughts on the study? I thought it was very interesting that the brain responses and pain rating of participants with FM were similar to the controls post-exercise and think that may be a strong point to make to patients with FM.
      2. While this article addressed participants with fibromyalgia, I think it provides simple to follow guidelines for aerobic exercise treatment in patients with chronic pain. I recently discussed utilizing the exercise parameters with a patient I am treating. What are your thoughts on the applicability of this type of aerobic exercise program for patients with chronic pain?
      3. How do you get patients who are not active to buy-in to performing continuous, moderate intensity aerobic exercise? How, if any, has the way you approached treating this population group changed over the course of the residency program?
      4. I have seen several patients with a history of FM but not as their primary complaint or reason for referral. Do you often incorporate this factor into your patients’ plan of care or believe that it may be a piece of the pie that is worthwhile treating in their care?

      If anything, I hope you can add this to your library of how physical activity has shown to be an effective treatment in different pain populations.

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    • #5254
      August Winter
      Participant

      1. I don’t often read articles with fMRI so this certainly was interesting. Any article that provides biological plausibility for what our clinical trials already are suggesting is a positive in my book. For application to clinical practice, this might be good evidence for starting a session with a longer aerobic activity in order to act as a window technique of sorts for harder functional or strength activities later.

      The biggest issue with this article is the ecological validity though, as how many patients do we see that have FM/chronic pain and do not have a comorbid psychological diagnosis?

      2. I think sometimes the traditional Borg RPE scale can be difficult for some patients to comprehend, but I do like the control it gives patients by telling them to raise/lower the difficulty as they see fit, just as long as they stay at a moderate effort level. I do know that some patients I have had with chronic pain get energized and motivated after a good day or a PT session and then go out and do too much activity, resulting in increased normal muscle fatigue and soreness that they might react negatively to. I think explicitly describing a “somewhat hard” difficulty might prevent this.

      3. First off, I think my approach with these patients has definitely changed in the past 6 months. As we’ve talked about before, asking questions instead of always telling can make a big difference. I think I am more explicitly trying to identify where people fall in the stages of change and then providing cues/education to reach the next stage. A big part of it is just trying to find something that they will even consider doing and then riding that train. I think I’ve found the most success with setting small weekly goals.

      4. When I get a referral for something like low back pain and the medical intake form also has FM marked on it for PMH, I typically try to do two seemingly opposing things 1) check the mostly negative connotations associated with that diagnosis at the door 2) realize that if my subjective and objective does rightly reinforce the initial clinical picture I have for this patient, that I will need to adjust my language/education and exercise prescription accordingly.

    • #5259
      Scott Resetar
      Participant

      1. What are your general thoughts on the study?

      N=9, so take that for what it’s worth. I loved that the authors were able to visually demonstrate the difference in brain processing with the BOLD response graphs (they look like onions). Further evidence that we can show people the problem is also in the central nervous system, and not just painful tissue. As August said, these patients had few comorbidities and no psychological diagnosis. You can take this as a pro or con. Pro: these patients might have “true” fibromyalgia, and give a clearer picture of the disease. Con: not generalizeable, and not an accurate picture of a more typical FM patient with depression/anxiety. Would love to see this study re-done with just people with depression, or just anxiety, and see if the results differ!

      2. This article seems like a great way to sell it to that hesitant patient. We all know looks at you like you are an alien when you ask them to try to do 10 minutes on the bike at level 6/10 intensity. Might be able to say well in this study they did 25 minutes, that’s our goal!

      3. I am constantly changing how I attempt to do this with patients. It’s so individualized. As August said, asking questions to identify stage of change is key. Find their motivation. Develop their trust in you. Develop their confidence in themselves. Small steps.

      4. I rarely see what you described, which is a patient who is here for XYZ pain/injury, who doesn’t relate it to their fibromyalgia diagnosis. I feel most of the time I see a patient who states this injury is worse because of the fibro. I first see if this person’s clinical presentation fits with their subjective/objective measures. If so, I often think about the state of their central nervous system and how it could reach to my wording about their injury and prognosis and may deliver my evaluation results a bit differently. If I see fibro on the intake form I always ask about it, and that leads me in the right direction. When were you diagnosed…how are you managing…what do you know about the disease… asking the right questions can help you determine how you are going to incorporate that diagnosis into your treatment and plan!

    • #5261
      Justin Bittner
      Participant

      1.
      I had to look up why left-handed people were excluded from the study. Apparently, lefties use both hemispheres for certain tasks that righties only use one hemisphere and can throw off results quite a bit. Sorry to the 10% of lefties with fibro this article doesn’t apply to. As already mentioned by Auggie-bear and Scott, it is rare to have a FM patient without psychosocial yellow flags. Though I feel this can be applied to most FM patients that would be one thing limiting its applicability.

      2.
      It is extremely difficult to get a patient to buy into the use of aerobic exercise for pain. The benefit of using this article as a reference is: A) the parameters are simple and allow the patient to have some control and B) the pictures of the fMRI signals can be used as a visual aid assisting with potential buy in.

      3.
      I have had one patient who I had bought into pain science and started seeing a conselor and was seeing significant improvements in pain and function. I know I talked to be about having a sensitized nervous system making manual therapy difficult.I talked to her about using 15-30 minutes of moderate aerobic exercise on the treamill (she liked walking) to lower her CNS sensitivity. This gave us a window to perform some manual therapy and allowed for specific therex to follow. This was a unique patient that I was able to get buy in at eval. I think what helped so much that day was relating her story to how she interpreted pain. She really seemed to “get it” when I could relate some pain science to her specific story.

      I have certainly failed a lot at getting buy in for these patients. But I think what was most helpful in this case was getting buy in early by relating her specific story to pain science. Once I had buy in and her trust, it opened more opportunities and her willingness to try what I had to offer.

      4.
      I’ll try to tease out if they think FM is related to their complaint and go from their. I feel like i Have a lot of patients that circle FM on the intake and write “possibly” or “not diagnosed” beside it. So, if its circled, I’ll ask them why they circled that and how they think their pain correlates with that. I’ll try to tailor the rest of my eval based on their response. Certainly, if they think it is related to their current complaint, it absolutely needs to be addressed based on their current belief system.

      • #5272
        August Winter
        Participant

        Justin, I’d love to hear your experience if you do use this as a visual aid with a patient, as I feel like I would struggle to be concise with breaking down what is happening in those visuals and why it matters to that patient. You are a much more charismatic man than I though…

        I do like your approach with directly asking about the FM from the intake form. Sometimes I wait to see if a patient makes a point of bringing it up on their own, especially if it is something like you mentioned where it is self diagnosed, but it might be better for everyone if it was addressed early.

        • #5282
          Justin Bittner
          Participant

          I have used the images a time or two from the research in JOSPT from 2013 using fMRI to show reductions in blood flow to pain areas of the brain following thoracic manipulation. My explanation was no more than, “the images show reduced activity in the pain areas of the brain following this technique”. Short and simple. Mainly because there is not a chance I could explain it in depth.

    • #5267
      Erik Lineberry
      Participant

      I have found that using graded movement/exercise with less heavy pain education has been more effective than using videos and pain explanations with every patient that I think has FM or chronic pain. I think this article backs that up. Unless I am mistaken the participants do not receive any pain science education at all. This has been a shift in my treatment for these patients recently and is mostly due to finding myself talking in circles and having better results giving a very basic explanation of the body/brain being “over-protective” and the exercise providing a means to show the body that movement is not a threat to calm down the protective responses. I will also list to patients the benefits of regular CV exercise including increased blood flow to promote healing, release endorphins, and promote analgesic responses and not even provide any of the pain science education or analogies we have talked about before.
      I find it difficult to use the Borg with everyone, but it is highly effective with patients that understand it. If the Borg isn’t going to work, I explain that I want the patient to find a CV exercise that they will do regularly and comfortably. We find a baseline distance or time and try to improve upon this week to week.
      When I see patients with FM in their history or patients that have self-diagnosed themselves with something via Dr. Google I have these kinds of treatments in the back of my mind if they are not responding the way I would expect from traditional intervention, but I try not to jump the gun on throwing them in the chronic pain bucket.
      Thanks for uploading this, it is a good article to keep on hand and was an interesting read. I love this stuff.

    • #5273
      August Winter
      Participant

      Question for Katie/everyone: is this an area of pain science research that should be emphasized in physical therapy research? In a JOSPT from mid last year the intro opinion article made a point of talking about how our pain science research should focus on decreased costs of care and translating current research into actual clinical practice. Which is more important to advance our work as clinicians?

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